You must make a determination whether the hotel you have selected is safe.  Reading reviews may provide some insight.  Also, searching the hotel surrounding using google street view may also provide clues.  Make certain the streets look safe enough to walk at night. Locating your hotel near the transit mode you will be using, such as a metro station, will reduce the amount of time you are on the street and hopefully reduce your exposure to risk.

Review the State Departments recommendations for Lodging Safety website for useful information.

If you are uncertain it may be worthwhile to search for an alternative place to stay.